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Abigail



「千と千尋の神隠し ::  Spirited Away」

posted 2 weeks ago on 6/10/2014 - 24,732 notes - via miyazakimania © yoshiohka
mindblowingscience:

Want the Best Medical Care? Swallow This Pill Covered in Tiny Needles.

When it comes to medicine, most people prefer pills to needles. But many drugs aren’t properly absorbed when taken in pill form. Now, researchers may have solved the problem: a digestible pill, covered with tiny needles, that injects drugs directly into your stomach lining.
The novel drug delivery system is the result of a collaboration between researchers at MIT and Massachusetts General Hospital. The concept for the pill is described in the video below, but the gist is as follows: A capsule is coated first with tiny needles, then a pH-sensitive coating. The coating not only makes it possible to swallow the pill, it also dissolves away in the low-pH environment of the stomach. When it does, the needles are exposed. Intestinal contractions carry the pill through the digestive tract while applying pressure to an internal drug reservoir. In this way, the drug is delivered via the needles into the intestinal wall, where it can be absorbed. Such a system could one day replace injections of medications like insulin, which are too big to be absorbed via the stomach, and prone to decomposition by gastrointestinal molecules, to be taken orally:
In the latest issue of the Journal of Pharmaceutical Sciences, researchers led by chemical engineer Carl Schoellhammer document the potential of the new drug delivery system. Using a pig as a model, the team demonstrated that injection into the intestines is an effective method of insulin-delivery. In a second experiment, the team showed that a pill measuring two centimeters long, 1 centimeter across, and coated in five-millimeter stainless-steel needles could pass safely through the digestive tract of a pig. Future versions of the pill could be coated with needles made of degradable polymers and sugars:

mindblowingscience:

Want the Best Medical Care? Swallow This Pill Covered in Tiny Needles.

When it comes to medicine, most people prefer pills to needles. But many drugs aren’t properly absorbed when taken in pill form. Now, researchers may have solved the problem: a digestible pill, covered with tiny needles, that injects drugs directly into your stomach lining.

The novel drug delivery system is the result of a collaboration between researchers at MIT and Massachusetts General Hospital. The concept for the pill is described in the video below, but the gist is as follows: A capsule is coated first with tiny needles, then a pH-sensitive coating. The coating not only makes it possible to swallow the pill, it also dissolves away in the low-pH environment of the stomach. When it does, the needles are exposed. Intestinal contractions carry the pill through the digestive tract while applying pressure to an internal drug reservoir. In this way, the drug is delivered via the needles into the intestinal wall, where it can be absorbed. Such a system could one day replace injections of medications like insulin, which are too big to be absorbed via the stomach, and prone to decomposition by gastrointestinal molecules, to be taken orally:

In the latest issue of the Journal of Pharmaceutical Sciencesresearchers led by chemical engineer Carl Schoellhammer document the potential of the new drug delivery system. Using a pig as a model, the team demonstrated that injection into the intestines is an effective method of insulin-delivery. In a second experiment, the team showed that a pill measuring two centimeters long, 1 centimeter across, and coated in five-millimeter stainless-steel needles could pass safely through the digestive tract of a pig. Future versions of the pill could be coated with needles made of degradable polymers and sugars:


posted 2 weeks ago on 2/10/2014 - 283 notes - via medicalexamination © io9.com

posted 3 weeks ago on 25/9/2014 - 25,711 notes - via miyazakimania © studioghiblish

art by He Jiaying

art by He Jiaying


posted 1 month ago on 31/8/2014 - 15,899 notes - via cantaloupemilk © reitsc

babyhongbin:

seoul sunset from my floor


posted 1 month ago on 31/8/2014 - 73,186 notes - via zutaras © cantaloupemilk

ruffnutrona:

asgardian-queen:

vladthehappyfangirlingpsycho:

virgo-dragon:

howtotrainyourdragenz:

asbehsam:

pitchpipestarkid:

ruffnutrona:

itosc12:

"Do you trust me? We can do this. You and me, as one."

epicness

Pure heaven, or should I say Valhala 😏

the most epic shit ever

PUT ON YOUR HEADPHONES AND LISTEN TO THIS

i literally can only listen to this at certain times because it makes me so emotional

This is the definition of epic

*cries*

Before now i did not believe music could reduce me to tears so quickly. This is beautiful!

I listen to this daily. Genuinely.


posted 1 month ago on 30/8/2014 - 3,507 notes - via dreamsoffools © asbehsam

jedavu:

Charming Illustrated Cinemagraphs Reflect The Idyllic Mood Of Lazy Summer Days

by Rebecca Mock 


posted 1 month ago on 26/8/2014 - 266,904 notes - via almacoin © jedavu


posted 1 month ago on 25/8/2014 - 2,499 notes - via totoros © moe-vampin